You suffer from indescribable pain and rebel to the point of wanting to “finish”. These intense and permanent pains leave you no respite. In addition, ending your life seems to be the only way to relieve yourself. These pains are all the more difficult to bear because they deprive you of all the riches of your life.
How to find peace and know the respites in this infernal circle?
Neuropathic pain can be destructive, but it is not inevitable. There are treatments to relieve it, at least in part.
What are the sources of neuropathic pain?
Neuropathic pain is pain that occurs spontaneously or abnormally as a result of nerve damage. These differ from messages of pain transmitted by the healthy nerves from injury to biological tissue (during a fall, cut or burn). Neuropathic pain is treated with different medications than those used to treat pain in damaged tissues and is commonly known as an analgesic.
Opioid analgesic drugs (such as morphine) are sometimes used to treat neuropathic pain. Morphine comes from plants, but many opioids are created in the laboratory rather than plant extracts. Tramadol is an opiate produced in the laboratory.
What is tramadol?
Tramadol is an analgesic or pain medication used in the treatment of moderate to severe pain (neuropathic pain).
The effectiveness of tramadol is reduced to synergy at therapeutic doses:
- an opioid effect due to the binding of receptor-type opioids,
- A central monoaminergic effect due to inhibition of reuptake of norepinephrine and serotonin on the control of central nociceptive transmission.
Like other products in this class, tramadol has antitussive properties. Effects on the gastrointestinal tract are low at therapeutic doses. The respiratory depressant effects of tramadol are the same as those of morphine. Animal studies have shown reduced dependence potential with morphine and a very low tolerance potential.
Tramadol is marketed under the names of Nobligan, Tiparol, Topalgic, Tradolan, Tramal, Ultram, Ixprim.
Are you wondering what is the effectiveness of tramadol?
Our studies conducted in February 2019, we conducted clinical trials in which tramadol was used to treat neuropathic pain in adults. 7 studies randomizing 673 participants on tramadol or placebo met the inclusion criteria. The duration of the studies was between 5 and 7 weeks. Some studies did not report the results we were interested in.
Our definition of a good outcome was that of a person with a high level of pain relief and the ability to continue taking the medication without side effects leading to discontinuation of treatment.
Small studies have shown that pain is reduced by half or more in some people. A reduction of half or more in the pain was felt by 6 people on tramadol and 4 out of 10 on placebo. Adverse events were observed in 6 out of 10 people with tramadol and 3 out of 10 with placebo, 3 out of 10 patients on tramadol and almost none of the placebo participants discontinued treatment due to side effects.
The evidence is of low quality. This means that the research has not proven credible for a likely effect and that the effect will likely be different from what has occurred in the analysis of these tests. Small studies such as those included in this article tend to overestimate treatment outcomes with the effects seen in larger, better-performed studies. There were also others that could lead to overly optimistic results. Evidence of low quality and significant benefits means that we need new large-scale trials before we can establish tramadol, which is useful for the management of neuropathic pain.
Prolonged use over several months may eventually lead to a state of dependence. In predisposed patients, treatment should be under strict medical supervision.
Tramadol is not suitable for withdrawal or substitution treatment in patients with opioid dependence. Although it is an opioid agonist, tramadol can not correct withdrawal symptoms of morphine.
Seizures have been reported in patients receiving tramadol at the recommended doses. The risk of seizures increases if doses of tramadol exceed the upper limit of the recommended daily dose (400 mg). Tramadol may also increase the risk of seizures in patients taking other products that lower the seizure threshold
Patients with epileptic seizures or convulsions are not treated with tramadol.
Taking alcohol during treatment is not recommended.
Due to the presence of lactose, this drug is contraindicated in case of congenital galactosemia, glucose-galactose malabsorption syndrome or lactase deficiency.
Precautions for use
Tramadol should only be used with careful evaluation of the benefit / risk ratio after the pain and the patient’s profile.
Tramadol should be used with caution in patients reporting intracranial hypertension, criminal trauma, loss of consciousness without apparent cause, or central or respiratory function disorders.
This medicine contains 214 mg of sodium per unit of price, taking into account the following people of a strict sodium diet.
This medicine contains lactose and aspartame